RELATED: The 20 Best Cleaning Tips We’ve Learned Over the Past 20 Years And while hand sanitizer is a convenient solution when we’re not at home, we learned that it’s not a replacement for regular old hand-washing with soap and water. RELATED: You’re Probably Making These 7 Hand-Washing Mistakes—Here’s What to Do Instead Plus, did you know that disinfecting works best if you clean a surface first? Translation: remove visible grime, crumbs, and dust before using a disinfecting wipe. RELATED: 7 Things You Should Sanitize Immediately to Avoid Getting Sick